Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Abstract Background The PI3K/AKT pathway is activated through PIK3CA or AKT1 mutations and PTEN loss in breast cancer.We conducted a phase II trial with an allosteric AKT inhibitor MK-2206 in patients with advanced breast cancer who had tumors with PIK3CA/AKT1 mutations and/or PTEN loss/mutation.Methods The primary endpoint was objective response r

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Giant-cell tumor of bone: treatment options and role of denosumab

Arun S Singh,1 Neal S Chawla,2 Sant P Chawla2 1Sarcoma Service, Division of Hematology/Oncology, University of California, Los Angeles, 2Sarcoma Oncology Center, Santa Monica, CA, USA Abstract: Giant-cell tumor of bone is a rare, locally aggressive tumor that typically occurs in the bones of skeletally mature young adults in their second to fourth

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Vehicle trajectory at curved sections of two-lane mountain roads: a field study under natural driving conditions

Abstract Purpose The trajectory of a vehicle is comprehensively affected by the interactions between the vehicle, the driving behavior, and the road environment.High-risk driving behaviors and accident-prone road sections can be identified based on the relationship between the trajectory and road geometry.Previous related studies mostly focused on

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